Dr Gavin M Brown
Email: g.brown@lancaster.ac.uk
Office: C13; Laboratory: B8
Department of Biological Sciences,
I.E.N.S.,
Lancaster University,
Lancaster, LA1 4YQ,
U.K. Tel: (44)1524 593252
Fax: (44)1524 593192 |
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Degrees
- 1989
B.Sc., Chemistry,
Lancaster
University
- 1992
Ph.D., Structural Biochemistry,
Lancaster
University
Academic Posts
- 1989-92
Research Assistant,
Lancaster
University
- 1992-94
Research Associate,
Lancaster
University
- 1994-2001
Lecturer in Biochemistry,
Lancaster
University
- 2001-present
Senior Lecturer in Biochemistry
Visiting Posts
- 1994-95
Visiting Scientist,
University
of
Dundee
Research Interests
My main research interests focus on a class of molecules called
proteoglycans that are
ke
y components on the cell surface and within extracellular matrices.
Proteoglycan research is a very rapidly expanding field as these
molecules are now known to have major roles in tissue organisation,
cell signalling, cell adhesion and host-pathogen interactions. My
research concentrates on the biomedical implications of proteoglycan
function and is designed to lead to a greater understanding of their
involvement in a variety of disease processes including the
development of osteo- and rheumatoid arthritis, the metastatic spread
of cancer and corneal eye disease.
Other research interests
include the role of alpha-synuclein in Parkinson’s Disease and the
development of optical biosensor technologies to study molecular
assemblies at the cell surface.
Current projects include:
·
The role of the small protein
dermatopontin in extracellular matrices
(funded by the Wellcome Trust).
·
The corneal phenotype of
dermatopontin-knockout mice
(funded
by the Wellcome Trust)
·
The role of the glycosylated form of
alpha-synuclein in juvenile Parkinson’s disease
(funded
by
Lancaster
University
)
·
Development of biosensor technologies
for studying multimolecular assemblies
(funded by BBSRC via a SBRI grant to Farfield Sensors Ltd.)
Current research collaborations:
At Lancaster – Prof. Ian
Nieduszynski, Dr.
Bob Lauder
, Dr. Nigel Fullwood, Prof. David Allsop, Dr. Fiona Benson, Dr. Alan
Thomson
Elsewhere – Prof. Hiroshi
Shinkai (
Chiba
,
Japan
), Farfield Biosensors (
Crewe
,
UK
)
Selected Publications
·
Cooper, L.J., Bentley, A.J.,
Nieduszynski, I.A., Talabani, S., Thomson, A., Utani, A., Shinkai, H.,
Fullwood
,
N.J.
& Brown, G.M. (2006)
Invest. Opthalmol. Vis. Sci. in
press “The Role of Dermatopontin in the Stromal Organisation of
the Cornea”.
·
Magro, G.,
Perissinotto, D., Schiappacassi, M., Goletz, S., Otto, A., Muller, E.C.,
Bisceglia, M., Brown, G.M., Ellis, T., Grasso, S., Colombatti,
A., Perris, R. (2003) Am. J. Pathol. 163, 183-96 "Proteomic
and postproteomic characterization of
ke
ratan sulfate-glycanated isoforms of thyroglobulin and transferrin
uniquely elaborated by papillary thyroid carcinomas".
·
Lauder, R.M., Huc
ke
rby, T.N., Nieduszynski, I.A. & Brown,
G.M. (2001) J. Biochem. 358,
523-528 “Age-Related Changes in the Chondroitin Sulphate Linkage
Region of Human Aggrecan”.
·
Galustian, C.,
Lubineau, A., le Narvor, C., Kiso, M., Brown, G.M. & Feizi,
T. (1999) J. Biol. Chem. 274, 18213-18217 "L-selectin
Interactions with Novel Multisulfated Lewisx Sequences in
Comparison with the Potant Ligand 3’-sulfated Lewisa".
·
Whitham, K.M.,
Hadley, J.L., Morris, H.G., Andrew, S.M., Nieduszynski, I.A. & Brown,
G.M. (1999) Glycobiology 9, 285-291 "An Improved
Method for the Structural Profiling of Keratan Sulphates: Analysis of
Keratan Sulphates from Brain and Ovarian Tumours".
·
Brown, G.M.,
Huc
ke
rby, T.N., Bayliss, M.T. & Nieduszynski, I.A. (1998) J. Biol.
Chem. 273, 26408 "Human Aggrecan Keratan Sulfate Undergoes
Structural Changes during Adolescent Development".
·
Brown, G.M.
& Nieduszynski, I.A. (1997) in A Laboratory Guide to
Glycoconjugate Analysis, Birkhauser Verlag AG, "Oligosaccharide
Profiling of Keratan Sulphate".
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